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Literature summary extracted from

  • Ivetac, I.; Munday, A.D.; Kisseleva, M.V.; Zhang, X.M.; Luff, S.; Tiganis, T.; Whisstock, J.C.; Rowe, T.; Majerus, P.W.; Mitchell, C.A.
    The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane (2005), Mol. Biol. Cell, 16, 2218-2233.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.66 additional information C2-domain deletion mutant, loss of enzyme activity, no localization to endosomes, no TAPP1 PH domain membrane recruitment Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.66 endosome early and recycling endosome Homo sapiens 5768
-
3.1.3.66 plasma membrane and endosome, after growth factor stimulation Homo sapiens 5886
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Organism

EC Number Organism UniProt Comment Textmining
3.1.3.66 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.66 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
-
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